Daily clinical reasoning series

December 2025

31 case-based clinical reasoning analyses assigned to the daily casebook sequence for December 2025.

Case-series dates · December 1, 2025 to December 31, 2025

Read Headache and Right-Upper-Quadrant Pain Late in Pregnancy
JT-CR-062 · Reproductive and postpartum care

Series

Headache and Right-Upper-Quadrant Pain Late in Pregnancy

Recognizes preeclampsia with severe features and HELLP while coordinating maternal stabilization, fetal assessment, and delivery planning.

preeclampsiaHELLP syndromesevere hypertension
Read Sudden Calf Pain During a Run
JT-CR-063 · Musculoskeletal, sports, and rehabilitation

Series

Sudden Calf Pain During a Run

Distinguishes muscle injury, ruptured Baker cyst, thrombosis, and compartment syndrome while planning safe return to activity.

calf straindeep vein thrombosisBaker cyst
Read First-Episode Psychosis With Recent Substance Exposure
JT-CR-064 · Mental, behavioral, and substance-use health

Series

First-Episode Psychosis With Recent Substance Exposure

Evaluates first psychosis across toxic, medical, mood, delirium, and primary psychotic causes while addressing safety and capacity.

first episode psychosissubstance exposuredelirium
Read Generalized Edema and Heavy Proteinuria
JT-CR-065 · Kidney, electrolytes, and digestive health

Series

Generalized Edema and Heavy Proteinuria

Frames nephrotic syndrome through edema physiology, secondary causes, thrombosis and infection risk, and biopsy decision-making.

nephrotic syndromeproteinuriahypoalbuminemia
Read Acute Epigastric Pain Radiating to the Back
JT-CR-066 · Kidney, electrolytes, and digestive health

Series

Acute Epigastric Pain Radiating to the Back

Confirms acute pancreatitis, identifies cause and severity, and calibrates fluids, nutrition, imaging, and complication monitoring.

acute pancreatitisgallstonesseverity assessment
Read Sudden Painless Vision Loss in One Eye
JT-CR-067 · Eye, skin, and digital safety

Series

Sudden Painless Vision Loss in One Eye

Treats acute monocular vision loss as an ocular and vascular emergency while separating retinal and media causes.

retinal artery occlusionretinal detachmentvitreous hemorrhage
Read Progressive Memory Change and Missed Bills
JT-CR-068 · Mental, behavioral, and substance-use health

Series

Progressive Memory Change and Missed Bills

Evaluates cognitive decline through function, reversible contributors, collateral history, driving, caregiving, and supported decisions.

cognitive impairmentinstrumental functiondementia evaluation
Read Fever, Bruising, and Pancytopenia: Marrow Emergency
JT-CR-069 · Cancer, blood, infection, and immunity

Series

Fever, Bruising, and Pancytopenia: Marrow Emergency

Recognizes neutropenic sepsis and marrow emergencies while distinguishing leukemia, aplasia, medicines, infection, and destructive causes.

pancytopenianeutropenic feveracute leukemia
Read Coughing Up Blood With a Normal Initial Radiograph
JT-CR-070 · Cancer, blood, infection, and immunity

Series

Coughing Up Blood With a Normal Initial Radiograph

Verifies true hemoptysis, protects the airway, and localizes malignant, infectious, inflammatory, and vascular causes despite normal radiography.

hemoptysisairway protectionlung cancer
Read A High-Severity Medication Alert Hidden in Alert Fatigue
JT-CR-071 · Medicines and care safety

Series

A High-Severity Medication Alert Hidden in Alert Fatigue

Verifies a dangerous interaction while redesigning clinical decision support to reduce false positives and preserve escalation reliability.

alert fatiguedrug interactionclinical decision support
Read Confusion During a Hot-Weather Endurance Event
JT-CR-072 · Mental, behavioral, and substance-use health

Series

Confusion During a Hot-Weather Endurance Event

Recognizes exertional heat stroke, prioritizes immediate cooling, and separates hyponatremia, exhaustion, and other collapse mechanisms.

exertional heat strokerapid coolingexercise hyponatremia
Read Resistant Hypertension and Low Potassium
JT-CR-073 · Diabetes and metabolic health

Series

Resistant Hypertension and Low Potassium

Plans primary aldosteronism screening, accounts for medication interference, confirms subtype, and reduces long-term cardiovascular risk.

resistant hypertensionhypokalemiaaldosterone renin ratio
Read Unintentional Weight Loss in an Older Adult
JT-CR-074 · Aging and palliative care

Series

Unintentional Weight Loss in an Older Adult

Investigates weight loss through malignancy, mood, oral health, medicines, endocrine disease, function, and food access.

unintentional weight lossmalnutritionolder adults
Read Fever and Refusal to Bear Weight in a Child
JT-CR-075 · Children and adolescent health

Series

Fever and Refusal to Bear Weight in a Child

Prioritizes septic hip and osteomyelitis while distinguishing transient synovitis, trauma, and malignancy without delaying aspiration.

septic arthritisosteomyelitispediatric limp
Read Hypotension After Abruptly Stopping Long-Term Steroids
JT-CR-076 · Diabetes and metabolic health

Series

Hypotension After Abruptly Stopping Long-Term Steroids

Recognizes adrenal crisis, treats before confirmation, preserves sepsis evaluation, and prevents recurrence through safe steroid transitions.

adrenal crisisglucocorticoid withdrawalshock
Read Fever, a New Murmur, and Injection Drug Use
JT-CR-077 · Cancer, blood, infection, and immunity

Series

Fever, a New Murmur, and Injection Drug Use

Coordinates endocarditis cultures, imaging, embolic assessment, source control, and evidence-based addiction care without stigma.

infective endocarditisblood culturesechocardiography
Read Fatigable Ptosis and Diplopia: Neuromuscular Localization
JT-CR-078 · Brain and neurologic health

Series

Fatigable Ptosis and Diplopia: Neuromuscular Localization

Distinguishes myasthenia from brainstem, thyroid, orbital, and cranial nerve disease while monitoring respiratory and medication hazards.

myasthenia gravisptosisdiplopia
Read Postpartum Fever and Uterine Tenderness
JT-CR-079 · Reproductive and postpartum care

Series

Postpartum Fever and Uterine Tenderness

Treats postpartum endometritis while separating retained tissue, urinary, wound, breast, thrombotic, and septic complications.

postpartum feverendometritisretained products
Read New Temporal Headache and Jaw Claudication
JT-CR-080 · Eye, skin, and digital safety

Series

New Temporal Headache and Jaw Claudication

Recognizes giant cell arteritis, protects vision before confirmation, and coordinates ultrasound or biopsy with polymyalgia assessment.

giant cell arteritisjaw claudicationvision protection
Read Little Sleep, Grandiosity, and Risky Spending
JT-CR-081 · Mental, behavioral, and substance-use health

Series

Little Sleep, Grandiosity, and Risky Spending

Distinguishes mania from substances, thyroid disease, psychosis, and delirium while selecting the least restrictive safe setting.

maniabipolar disordersubstance exposure
Read Visible Hematuria After an Upper-Respiratory Illness
JT-CR-082 · Men's health and urology

Series

Visible Hematuria After an Upper-Respiratory Illness

Localizes glomerular bleeding, evaluates IgA nephropathy and nephritic urgency, and preserves urologic assessment when features conflict.

hematuriaIgA nephropathyproteinuria
Read Progressive Difficulty Swallowing Solids: Obstruction Assessment
JT-CR-083 · Kidney, electrolytes, and digestive health

Series

Progressive Difficulty Swallowing Solids: Obstruction Assessment

Evaluates mechanical obstruction, cancer, eosinophilic disease, and motility while protecting nutrition and aspiration safety.

dysphagiaesophageal cancereosinophilic esophagitis
Read Forehead Vesicles and Eye Pain
JT-CR-084 · Eye, skin, and digital safety

Series

Forehead Vesicles and Eye Pain

Recognizes ophthalmic zoster, starts timely antiviral care, and coordinates urgent eye evaluation despite limited bedside examination.

ophthalmic zostereye paincorneal disease
Read Confusion and Urinary Retention After a Medication Change
JT-CR-085 · Kidney, electrolytes, and digestive health

Series

Confusion and Urinary Retention After a Medication Change

Identifies anticholinergic toxicity, delirium, constipation, and obstruction while using safe deprescribing and transition follow-through.

anticholinergic burdendeliriumurinary retention
Read Persistent Incidental Lymphocytosis: Clonal Risk Assessment
JT-CR-086 · Cancer, blood, infection, and immunity

Series

Persistent Incidental Lymphocytosis: Clonal Risk Assessment

Separates reactive from clonal lymphocytosis through trend, smear, flow cytometry, red flags, and proportionate surveillance.

lymphocytosisflow cytometryCLL
Read Daytime Sleepiness, Snoring, and a Near-Miss Crash
JT-CR-087 · Eye, skin, and digital safety

Series

Daytime Sleepiness, Snoring, and a Near-Miss Crash

Evaluates obstructive sleep apnea, insufficient sleep, narcolepsy, sedatives, and driving risk after a near-miss collision.

sleep apneadaytime sleepinessdrowsy driving
Read Diagnostic Closure During a Language-Discordant Visit
JT-CR-088 · Medicines and care safety

Series

Diagnostic Closure During a Language-Discordant Visit

Uses professional interpretation, teach-back, symptom reconstruction, and record design to recover missed diagnostic information safely.

professional interpretationdiagnostic errorteach-back
Read New Postpartum Breathlessness and Orthopnea
JT-CR-089 · Reproductive and postpartum care

Series

New Postpartum Breathlessness and Orthopnea

Recognizes peripartum cardiomyopathy while evaluating pulmonary embolism, preeclampsia complications, infection, and physiologic recovery.

peripartum cardiomyopathypostpartum dyspneaheart failure
Read Claudication With a Nonhealing Toe Wound
JT-CR-090 · Brain and neurologic health

Series

Claudication With a Nonhealing Toe Wound

Recognizes chronic limb-threatening ischemia, excludes acute limb danger, and integrates perfusion, wound, neuropathy, and revascularization care.

peripheral artery diseasetoe ulcerlimb ischemia
Read Polyuria, Constipation, and Hypercalcemia: Etiologic Assessment
JT-CR-091 · Diabetes and metabolic health

Series

Polyuria, Constipation, and Hypercalcemia: Etiologic Assessment

Confirms clinically meaningful hypercalcemia and separates parathyroid, malignant, medication, and volume-related causes using targeted physiology.

hypercalcemiahyperparathyroidismmalignancy
Read Bilious Vomiting in a Newborn
JT-CR-092 · Children and adolescent health

Series

Bilious Vomiting in a Newborn

Treats green emesis as surgical obstruction until proven otherwise, prioritizing stabilization, urgent imaging, and neonatal surgery coordination.

bilious vomitingmalrotationmidgut volvulus