Daily clinical reasoning series

October 2025

31 case-based clinical reasoning analyses assigned to the daily casebook sequence for October 2025.

Case-series dates · October 1, 2025 to October 31, 2025

Read Nonclassic Chest Discomfort in Urgent Care
JT-CR-001 · Emergency and acute care

Series

Nonclassic Chest Discomfort in Urgent Care

An original case on recognizing possible acute coronary syndrome when the first description sounds like indigestion rather than chest pain.

acute coronary syndromechest discomforturgent care
Read Iron-Deficiency Anemia in Ambulatory Care
JT-CR-002 · Cancer, blood, infection, and immunity

Series

Iron-Deficiency Anemia in Ambulatory Care

An original adult case on confirming iron deficiency, finding its cause, and reasoning through gastrointestinal blood loss and celiac disease.

iron-deficiency anemiaceliac diseasegastrointestinal evaluation
Read Falls, Dizziness, and Orthostatic Hypotension
JT-CR-003 · Aging and palliative care

Series

Falls, Dizziness, and Orthostatic Hypotension

An original older-adult case linking recurrent falls, postural symptoms, medication burden, mobility, and a tailored prevention plan.

older-adult fallsorthostatic hypotensionpolypharmacy
Read Fever in a Young Infant Without a Clear Source
JT-CR-004 · Children and adolescent health

Series

Fever in a Young Infant Without a Clear Source

An original case on age-banded evaluation, invasive infection risk, lumbar puncture uncertainty, and safe follow-up for infant fever.

febrile infantinvasive bacterial infectionmeningitis
Read Adolescent Depression, Safety, and Confidentiality
JT-CR-005 · Mental, behavioral, and substance-use health

Series

Adolescent Depression, Safety, and Confidentiality

An original case on depression assessment, suicide safety, caregiver involvement, confidential care, and closed-loop follow-up.

adolescent depressionsuicide safetyconfidentiality
Read Pain and Bleeding in Early Pregnancy
JT-CR-006 · Reproductive and postpartum care

Series

Pain and Bleeding in Early Pregnancy

An original case on pregnancy of unknown location, ectopic danger, serial hCG limits, repeat ultrasound, and safe follow-up.

early pregnancy painvaginal bleedingpregnancy of unknown location
Read Acute Kidney Injury With a Rising Potassium
JT-CR-007 · Kidney, electrolytes, and digestive health

Series

Acute Kidney Injury With a Rising Potassium

An original inpatient case on acute kidney injury, dangerous hyperkalemia, temporary stabilization, potassium removal, and reassessment.

acute kidney injuryhyperkalemiainpatient medicine
Read New Confusion During an Inpatient Stay
JT-CR-008 · Brain and neurologic health

Series

New Confusion During an Inpatient Stay

An original older-adult case on recognizing delirium, finding interacting causes, avoiding reflex treatment, and planning a safe transition.

deliriumolder adultinpatient medicine
Read Chronic Cough at a Telehealth Visit
JT-CR-009 · Lung and sleep health

Series

Chronic Cough at a Telehealth Visit

An original adult case on chronic-cough triage by video, red flags, in-person testing, treatable traits, and explicit telehealth limits.

chronic coughtelehealthchest radiograph
Read Childhood Asthma Control at Home and School
JT-CR-010 · Children and adolescent health

Series

Childhood Asthma Control at Home and School

An original case on recognizing poor childhood asthma control and building one workable safety plan across home, school, sports, and two caregiving households.

childhood asthmaasthma action planschool health
Read Medication Reconciliation After Heart Failure Discharge
JT-CR-011 · Medicines and care safety

Series

Medication Reconciliation After Heart Failure Discharge

A case on resolving discordant heart-failure medicine lists while monitoring volume, blood pressure, kidney function, and potassium.

heart failuremedication reconciliationcare transitions
Read Prioritizing Prevention When Visit Time Is Short
JT-CR-012 · Prevention, rural health, and care systems

Series

Prioritizing Prevention When Visit Time Is Short

A case on prioritizing prevention when records are incomplete, time is limited, and completing screening requires more than placing orders.

preventive carecancer screeningvaccination
Read Fever, Jaundice, and Right-Upper-Quadrant Pain
JT-CR-013 · Kidney, electrolytes, and digestive health

Series

Fever, Jaundice, and Right-Upper-Quadrant Pain

An original emergency case on recognizing acute cholangitis, separating biliary mimics, and coordinating urgent drainage and sepsis care.

acute cholangitisjaundicebiliary obstruction
Read New Diabetes With Weight Loss and Ketosis
JT-CR-014 · Diabetes and metabolic health

Series

New Diabetes With Weight Loss and Ketosis

An original adult case on diabetic ketoacidosis triage, safe metabolic correction, and diabetes classification after the crisis.

diabetic ketoacidosisnew diabetesketosis
Read Fever During Chemotherapy Before the Neutrophil Count Is Known
JT-CR-015 · Cancer, blood, infection, and immunity

Series

Fever During Chemotherapy Before the Neutrophil Count Is Known

An original case on urgent fever triage during cytotoxic chemotherapy, source evaluation, antimicrobial timing, and disposition uncertainty.

fever during chemotherapyfebrile neutropeniaoncology emergency
Read The Hot Swollen Knee and the Aspiration Decision
JT-CR-016 · Musculoskeletal, sports, and rehabilitation

Series

The Hot Swollen Knee and the Aspiration Decision

An original case on septic arthritis, crystal mimics, urgent aspiration, synovial-test interpretation, treatment, and safety planning.

hot swollen kneeseptic arthritiscrystal arthritis
Read Painful Red Eye With Photophobia and Reduced Vision
JT-CR-017 · Eye, skin, and digital safety

Series

Painful Red Eye With Photophobia and Reduced Vision

An original urgent-care case on separating microbial keratitis from angle closure, uveitis, scleritis, and common red-eye mimics.

painful red eyephotophobiareduced vision
Read Altered Mental Status After an Unknown Ingestion
JT-CR-018 · Emergency and acute care

Series

Altered Mental Status After an Unknown Ingestion

An original emergency case on stabilization, toxidrome reasoning, test limits, poison-center coordination, and safe disposition.

altered mental statusunknown ingestiontoxicology
Read Lower Urinary Tract Symptoms With New Hematuria
JT-CR-019 · Men's health and urology

Series

Lower Urinary Tract Symptoms With New Hematuria

An original case on lower urinary tract symptoms, retention risk, visible hematuria, medication safety, and accountable urology follow-up.

lower urinary tract symptomshematuriaurinary retention
Read A Painless Testicular Mass and Fertility Priorities
JT-CR-020 · Men's health and urology

Series

A Painless Testicular Mass and Fertility Priorities

An original case on a painless testicular mass, urgent ultrasound, tumor-marker limits, fertility preservation, and closed-loop referral.

testicular masstesticular cancerscrotal ultrasound
Read Planning Alcohol Cessation When Withdrawal Risk Is High
JT-CR-021 · Mental, behavioral, and substance-use health

Series

Planning Alcohol Cessation When Withdrawal Risk Is High

An original case on predicting severe alcohol withdrawal, choosing level of care, medication safety, warm handoffs, and continuing treatment.

alcohol withdrawalalcohol use disorderwithdrawal seizure
Read Opioid Use Disorder Across a Hospital-to-Clinic Transition
JT-CR-022 · Mental, behavioral, and substance-use health

Series

Opioid Use Disorder Across a Hospital-to-Clinic Transition

An original case on OUD treatment continuity, withdrawal, overdose prevention, pain, naloxone, stigma, and a closed-loop hospital handoff.

opioid use disorderbuprenorphinemethadone
Read Breathlessness During Serious Illness at Home
JT-CR-023 · Aging and palliative care

Series

Breathlessness During Serious Illness at Home

An original case on reversible causes of palliative dyspnea, symptom relief, opioid safety, goals, caregiver capacity, and home crisis planning.

palliative dyspneabreathlessnesshome care
Read Nausea and Constipation During Serious Illness
JT-CR-024 · Aging and palliative care

Series

Nausea and Constipation During Serious Illness

An original case on cause-directed nausea and constipation assessment, obstruction, medication burden, deprescribing, antiemetic safety, and home follow-up.

palliative nauseaconstipationbowel obstruction
Read Mixed Acid-Base Disturbance After a High-Output Ostomy
JT-CR-025 · Kidney, electrolytes, and digestive health

Series

Mixed Acid-Base Disturbance After a High-Output Ostomy

An original case on high ostomy output, mixed acid-base interpretation, kidney injury, replacement, and safer post-discharge monitoring.

high-output ostomyacid-basedehydration
Read Longitudinal Multimorbidity When Rural Follow-Up Is Limited
JT-CR-026 · Prevention, rural health, and care systems

Series

Longitudinal Multimorbidity When Rural Follow-Up Is Limited

An original case on competing guideline burdens, deprescribing, feasible rural monitoring, shared goals, and closed-loop escalation.

multimorbidityrural healthpolypharmacy
Read Pulmonary Nodule Follow-Up Across Rural Systems
JT-CR-027 · Lung and sleep health

Series

Pulmonary Nodule Follow-Up Across Rural Systems

An original case on nodule risk, guideline scope, prior-image retrieval, rural imaging access, shared decisions, and closed-loop follow-up.

pulmonary noduleincidental findingrural health
Read Pressure Injury Risk, Access, and Wheelchair Seating
JT-CR-028 · Musculoskeletal, sports, and rehabilitation

Series

Pressure Injury Risk, Access, and Wheelchair Seating

An original case on accessible skin assessment, pressure injury staging, infection risk, seating, nutrition, continence, equipment, and home prevention.

pressure injurywheelchair seatingwound care
Read An Ungradable Retinal Screening Image and Closed-Loop Referral
JT-CR-029 · Eye, skin, and digital safety

Series

An Ungradable Retinal Screening Image and Closed-Loop Referral

An original case on image quality, non-diagnostic screening, closed-loop referral, and equitable follow-through.

artificial intelligencediabetic retinopathyretinal screening
Read The Transition Home After Stroke Rehabilitation
JT-CR-030 · Brain and neurologic health

Series

The Transition Home After Stroke Rehabilitation

An original case on stroke discharge home, prevention, swallowing, mobility, communication, caregiver training, equipment, and rural follow-up.

stroke rehabilitationtransition homedysphagia
Read Deconditioning and Recovery After Critical Illness
JT-CR-031 · Musculoskeletal, sports, and rehabilitation

Series

Deconditioning and Recovery After Critical Illness

An original case on post-ICU weakness, differential diagnosis, cognitive and emotional recovery, rehabilitation, nutrition, medicines, and home safety.

post-intensive care syndromeICU-acquired weaknessrehabilitation