Daily clinical reasoning series

April 2026

30 case-based clinical reasoning analyses assigned to the daily casebook sequence for April 2026.

Case-series dates · April 1, 2026 to April 30, 2026

Read Hypothermia, Bradycardia, and Altered Mental Status
JT-CR-183 · Mental, behavioral, and substance-use health

Series

Hypothermia, Bradycardia, and Altered Mental Status

An environmental emergency case on gentle handling, staged rewarming, arrhythmia risk, and endocrine or toxic mimics.

hypothermiabradycardiarewarming
Read Tearing Chest Pain With Unequal Pulses
JT-CR-184 · Heart and vascular care

Series

Tearing Chest Pain With Unequal Pulses

An acute aortic syndrome case on probability, CTA, impulse control, branch ischemia, and immediate surgical pathways.

aortic dissectionacute aortic syndromeunequal pulses
Read An Incidental Positive ANA Without Systemic Features
JT-CR-185 · Musculoskeletal, sports, and rehabilitation

Series

An Incidental Positive ANA Without Systemic Features

A pretest-probability case on ANA false positives, symptom-led testing, reflex panels, and avoiding an unsupported autoimmune label.

antinuclear antibodyANAfalse positive
Read Hypertension in an Adolescent With Obesity
JT-CR-186 · Children and adolescent health

Series

Hypertension in an Adolescent With Obesity

A pediatric blood-pressure case on accurate measurement, ambulatory confirmation, obesity, kidney and endocrine causes, and family care.

adolescent hypertensionambulatory blood pressurepediatric obesity
Read Hypernatremia in an Older Adult With Limited Water Access
JT-CR-187 · Aging and palliative care

Series

Hypernatremia in an Older Adult With Limited Water Access

A water-balance case on deficit, impaired access, AVP disorders, osmotic losses, correction, and recurrence prevention.

hypernatremiadehydrationwater access
Read A New HIV Diagnosis in Primary Care
JT-CR-188 · Cancer, blood, infection, and immunity

Series

A New HIV Diagnosis in Primary Care

A stigma-aware case on diagnostic confirmation, rapid linkage, baseline evaluation, treatment, prevention, and durable retention.

HIV diagnosisantiretroviral therapylinkage to care
Read Painful Monocular Vision Loss in a Young Adult
JT-CR-189 · Eye, skin, and digital safety

Series

Painful Monocular Vision Loss in a Young Adult

An optic-neuritis case distinguishing demyelination from ischemic, infectious, retinal, orbital, and pressure emergencies.

optic neuritismonocular vision lossmultiple sclerosis
Read Painful Vulvar Lesions After a New Partnership
JT-CR-190 · Eye, skin, and digital safety

Series

Painful Vulvar Lesions After a New Partnership

A confidential genital-ulcer case on herpes, syphilis, inflammatory dermatoses, trauma, testing windows, and prevention.

genital ulcerherpes simplexsyphilis
Read Nocturnal Hand Numbness and Weak Grip
JT-CR-191 · Men's health and urology

Series

Nocturnal Hand Numbness and Weak Grip

A localization case separating carpal tunnel syndrome from cervical radiculopathy, polyneuropathy, and urgent motor loss.

carpal tunnel syndromemedian neuropathyhand numbness
Read An Adult Requesting an ADHD Diagnosis
JT-CR-192 · Mental, behavioral, and substance-use health

Series

An Adult Requesting an ADHD Diagnosis

A lifespan case on developmental history, impairment, mood, sleep, anxiety, substances, trauma, and safe treatment planning.

adult ADHDdevelopmental historyexecutive function
Read A Painful Ulcer That Worsens After Debridement
JT-CR-193 · Eye, skin, and digital safety

Series

A Painful Ulcer That Worsens After Debridement

A pyoderma-gangrenosum case on pathergy, infection and vasculitis exclusion, biopsy purpose, pain, and coordinated wound care.

pyoderma gangrenosumpathergypainful ulcer
Read Driving Concerns With Mild Cognitive Impairment
JT-CR-194 · Men's health and urology

Series

Driving Concerns With Mild Cognitive Impairment

A mobility-centered case on functional driving risk, vision, medicines, law, reporting, and preserving community access.

mild cognitive impairmentdriving safetyfunctional assessment
Read Escalating Pain Under a New Cast
JT-CR-195 · Emergency and acute care

Series

Escalating Pain Under a New Cast

An acute-compartment-syndrome case on serial examination, analgesia misconceptions, pressure testing, and emergency decompression.

compartment syndromecast complicationpain with passive stretch
Read Hypotension Without Fever in an Immunosuppressed Adult
JT-CR-196 · Diabetes and metabolic health

Series

Hypotension Without Fever in an Immunosuppressed Adult

Recognizes afebrile septic shock, adrenal crisis, hemorrhage, and cardiogenic causes when immunosuppression blunts expected signs.

immunosuppressionseptic shockadrenal crisis
Read A Bicuspid Aortic Valve Found Incidentally
JT-CR-197 · Heart and vascular care

Series

A Bicuspid Aortic Valve Found Incidentally

Turns an incidental bicuspid valve into a structured assessment of valve function, aortic dimensions, family screening, and surveillance.

bicuspid aortic valveaortopathyechocardiography
Read A Positive Stool Screening Test With No Symptoms
JT-CR-198 · Cancer, blood, infection, and immunity

Series

A Positive Stool Screening Test With No Symptoms

Explains why an abnormal stool screening result needs diagnostic colonoscopy, timely navigation, and closure even without symptoms.

fecal immunochemical testcolorectal screeningcolonoscopy
Read Bronchiolitis in an Infant With Increased Work of Breathing
JT-CR-199 · Children and adolescent health

Series

Bronchiolitis in an Infant With Increased Work of Breathing

Uses feeding, apnea risk, oxygenation, hydration, and serial respiratory effort to guide supportive bronchiolitis care.

bronchiolitisinfant respiratory distressfeeding
Read Fragility Fracture in Advanced CKD
JT-CR-200 · Musculoskeletal, sports, and rehabilitation

Series

Fragility Fracture in Advanced CKD

Separates fracture care, osteoporosis risk, and renal osteodystrophy before choosing bone therapy in advanced chronic kidney disease.

fragility fractureadvanced CKDrenal osteodystrophy
Read Fever and Diarrhea After Travel
JT-CR-201 · Kidney, electrolytes, and digestive health

Series

Fever and Diarrhea After Travel

Uses itinerary, incubation, severity, malaria testing, cultures, and public health clues to evaluate febrile diarrhea after travel.

returned travelerfebrile diarrheaenteric fever
Read Recurrent Visual Aura in an Older Adult
JT-CR-202 · Men's health and urology

Series

Recurrent Visual Aura in an Older Adult

Distinguishes stereotyped migraine aura from retinal ischemia, TIA, seizure, and ocular disease when visual episodes begin later in life.

visual auratransient ischemic attackmigraine
Read Preconception Review for Chronic-Disease Medicines
JT-CR-203 · Reproductive and postpartum care

Series

Preconception Review for Chronic-Disease Medicines

Balances disease control, reproductive timing, medicine risk, contraception, monitoring, and shared decisions before pregnancy.

preconception caremedication reconciliationchronic disease
Read An Ankle Inversion Injury With Difficulty Walking
JT-CR-204 · Musculoskeletal, sports, and rehabilitation

Series

An Ankle Inversion Injury With Difficulty Walking

Applies fracture rules, targeted examination, imaging, functional support, and reassessment after an acute inversion injury.

ankle inversionOttawa ankle ruleslateral ligament sprain
Read Multiple Physical Symptoms After Repeated Negative Tests
JT-CR-205 · Prevention, rural health, and care systems

Series

Multiple Physical Symptoms After Repeated Negative Tests

Builds a validating, bounded evaluation and functional treatment plan for persistent symptoms without missing new objective disease.

persistent physical symptomssomatic symptom disorderdiagnostic stewardship
Read Fever and Reduced Urine Output After Kidney Transplant
JT-CR-206 · Kidney, electrolytes, and digestive health

Series

Fever and Reduced Urine Output After Kidney Transplant

Prioritizes sepsis, obstruction, rejection, drug toxicity, and graft perfusion when fever accompanies acute allograft dysfunction.

kidney transplantoliguriaallograft dysfunction
Read Markedly Elevated Aminotransferases After Strenuous Exercise
JT-CR-207 · Diabetes and metabolic health

Series

Markedly Elevated Aminotransferases After Strenuous Exercise

Distinguishes muscle release from acute hepatic injury using CK, bilirubin, INR, exposure history, kidney risk, and enzyme trajectory.

aminotransferasesstrenuous exerciserhabdomyolysis
Read Blisters, Skin Pain, and Mucosal Erosions After a New Medicine
JT-CR-208 · Eye, skin, and digital safety

Series

Blisters, Skin Pain, and Mucosal Erosions After a New Medicine

Recognizes Stevens-Johnson syndrome and toxic epidermal necrolysis, stops culprit exposure, and protects skin, eyes, airway, and fluids.

Stevens-Johnson syndrometoxic epidermal necrolysisdrug eruption
Read Preventing Delirium Around Major Surgery
JT-CR-209 · Aging and palliative care

Series

Preventing Delirium Around Major Surgery

Builds a multicomponent perioperative plan around cognition, medicines, mobility, sleep, sensory access, hydration, and family knowledge.

delirium preventionmajor surgeryolder adult
Read Sickle-Cell Pain With Fever and Falling Oxygen Saturation
JT-CR-210 · Cancer, blood, infection, and immunity

Series

Sickle-Cell Pain With Fever and Falling Oxygen Saturation

Recognizes evolving acute chest syndrome during a pain episode and coordinates analgesia, oxygenation, infection treatment, spirometry, and transfusion.

sickle cell diseaseacute chest syndromevaso-occlusive pain
Read Progressive Dyspnea With Signs of Pulmonary Hypertension
JT-CR-211 · Heart and vascular care

Series

Progressive Dyspnea With Signs of Pulmonary Hypertension

Moves from echocardiographic probability to etiologic classification and right heart catheterization before pulmonary vascular therapy.

pulmonary hypertensionright heart catheterizationCTEPH
Read A Copied-Forward Diagnosis That No Longer Fits
JT-CR-212 · Medicines and care safety

Series

A Copied-Forward Diagnosis That No Longer Fits

Repairs an inherited diagnosis by tracing provenance, comparing current evidence, correcting downstream records, and preserving uncertainty.

copy forwardproblem listdiagnostic error